A Tissue Box is an item in Nintendogs that falls under the category of "Etc." in the Supplies. It is an orange & white box of tissues that says "Tissue" on it. You can throw it around the room for your puppy to play with. It can easily be found on walks and sells for $1 at the Secondhand Shop.Most dogs will play with it, and all breeds can pick it up and bring it back. Sometimes the tissues may go through the dog's nose, imitating the dog wiping its nose. That only occurs on dogs with long muzzles, like Shelties or German sheperds.
DS: "This is just a box of tissues. It's good for runny noses, not wet puppy noses."